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INDICATION

CYANOKIT (hydroxocobalamin for injection) 5 g for intravenous infusion is indicated for the treatment of known or suspected cyanide poisoning. If clinical suspicion of cyanide poisoning is high, CYANOKIT should be administered without delay.

The product information provided in this site is intended only for emergency personnel and healthcare professionals in the United States.The products discussed herein may have different product labeling in different countries.

References

References

  1. CYANOKIT (single 5-g vial) [package insert]. Columbia, MD: Meridian Medical Technologies, Inc.; 2017.
  2. Eckstein M, Maniscalco PM. Focus on smoke inhalation–the most common cause of acute cyanide poisoning. Prehosp Disaster Med. 2006;21(2):s49-s55.
  3. Borron SW, Baud FJ, Barriot P, Imbert M, Bismuth C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg Med. 2007;49(6):794-801.
  4. Borron SW, Stonerook M, Reid F. Efficacy of hydroxocobalamin for the treatment of acute cyanide poisoning in adult beagle dogs. Clin Toxicol (Phila). 2006;44(suppl 1):5-15.
  5. Lawson-Smith P, Jansen EC, Hyldegaard O. Cyanide intoxication as part of smoke inhalation–a review on diagnosis and treatment from the emergency perspective. Scand J Trauma Resusc Emerg Med. 2011;19:1-5.
  6. Baud FJ, Borron SW, Mégarbane B, et al. Value of lactic acidosis in the assessment of the severity of acute cyanide poisoning. Crit Care Med. 2002;30(9):2044-2050.
  7. Lee-Chiong TL Jr. Smoke inhalation injury: when to suspect and how to treat. Postgrad Med. 1999;105(2):55-62.
  8. Borron SW, Baud FJ, Megarbane B, Bismuth C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg Med. 2007;25(5):551-558.
  9. Uhl W, Nolting A, Golor G, Rost KL, Kovar A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila). 2006;44(suppl 1):17-28.
  10. Guidotti T. Acute cyanide poisoning in prehospital care: new challenges, new tools for intervention. Prehosp Disaster Med. 2005;21(2):s40-s48.
  11. Walsh DW, Eckstein M. Hydrogen cyanide in fire smoke: an underappreciated threat. Emerg Med Serv. 2004;33(10):160-163.
  12. Research Triangle Institute International. Cyanide: understanding the risk, enhancing preparedness. Clin Toxicol (Phila). 2006;44(suppl 1):S47-S63.
  13. Keim ME. Terrorism involving cyanide: the prospect of improving preparedness in the prehospital setting. Prehosp Disaster Med. 2006;21(2):s56-s60.
  14. FDA Press Release. FDA approves drug to treat cyanide poisoning. US Food and Drug Administration. December 15, 2006.
  15. EMEA. European Public Assessment Report. CYANOKIT, 2007.
  16. Borron SW. Recognition and treatment of acute cyanide poisoning. J Emerg Nurs. 2006;32(4 suppl):s12-s18.
  17. Stevens J. Carbon monoxide and cyanide poisoning in smoke inhalation victims: a review. Trauma Report. 2015;1-19.
  18. FEMA. Authorized equipment list. https://www.fema.gov/authorized-equipment-list-item/09ph-05-cobl. Accessed May 4, 2017.
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