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Historical Instances of Cyanide Poisoning

Because of its widely recognized toxic effects, cyanide has been employed around the world to intentionally poison victims, engage in mass suicide, and commit genocide in wartime. Its versatility and ease of use has enabled it to be used in a range of targets—such as subways and water supplies—in the form of gas, powder, and other modes of delivery.²⁸

Learn more about the historical uses of cyanide.

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Indication
CYANOKIT^® (hydroxocobalamin for injection) 5 g for intravenous use is indicated for the treatment of known or suspected cyanide poisoning. If clinical suspicion of cyanide poisoning is high, CYANOKIT^® should be administered without delay.

Important Safety Information
Cyanide poisoning may result from inhalation, ingestion, or dermal exposure. Prior to administration of CYANOKIT^®, smoke-inhalation victims should be assessed for: exposure to fire or smoke in an enclosed area; presence of soot around the mouth, nose, or oropharynx; and altered mental status. In addition to CYANOKIT^®, treatment of cyanide poisoning must include immediate attention to airway patency, adequacy of oxygenation and hydration, cardiovascular support, and management of any seizure activity.

Use caution in the management of patients with known anaphylactic reactions to hydroxocobalamin or cyanocobalamin. Allergic reactions may include anaphylaxis, chest tightness, edema, urticaria, pruritus, dyspnea, rash, and angioneurotic edema. Substantial increases in blood pressure may occur following treatment with CYANOKIT^®.

The most common adverse reactions (>5%) are transient and include chromaturia, erythema, rash (acneiform), increased blood pressure, nausea, headache, decreased lymphocyte percentage, and injection site reactions. Usage may interfere with some clinical laboratory evaluations. Due to potential photosensitivity patients should avoid direct sun until erythema resolves.

CYANOKIT^® is Pregnancy Category C and should be used during pregnancy only if the potential benefit justifies the potential risk. Safety and effectiveness of CYANOKIT^® have not been established in pediatrics.

Please see full Prescribing Information.

DISCLAIMER
The content of this Web site is not and should not be construed as medical advice. The content contained herein only constitutes commentary and is for educational and information purposes only. Reading this Web site, or any other interaction on this site, does not create a relationship between you and the Web site or its registered owner. As with any medical issue that may confront you in a particular situation, you should always consult a qualified healthcare professional.

This Web site is intended for United States of America (U.S.A.) residents only and is subject to all applicable U.S.A. laws. CYANOKIT^® is a registered trademark of Merck Santé s.a.s., licensed by Meridian Medical Technologies^®, Inc., a wholly owned subsidiary of King Pharmaceuticals^®, Inc. Copyright © 2010 Meridian Medical Technologies^®, Inc., a wholly owned subsidiary of King Pharmaceuticals^®, Inc. All rights reserved. MMT6577A 03/2010

The expert advice of a regional poison control center may be obtained by calling 1-800-222-1222.