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In Case of Emergency

Call 911 for immediate assistance with cyanide poisoning or suspected cyanide poisoning.
The expert advice of a regional poison control center may be obtained by calling 1-800-222-1222.

This national hotline number will let you talk to experts in poisoning. This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. You can call for any reason, 24 hours a day, 7 days a week. American Association of Poison Control Centers—www.aapcc.org.

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Indication
CYANOKIT^® (hydroxocobalamin for injection) 5 g for intravenous use is indicated for the treatment of known or suspected cyanide poisoning. If clinical suspicion of cyanide poisoning is high, CYANOKIT^® should be administered without delay.

Important Safety Information
Cyanide poisoning may result from inhalation, ingestion, or dermal exposure. Prior to administration of CYANOKIT^®, smoke-inhalation victims should be assessed for: exposure to fire or smoke in an enclosed area; presence of soot around the mouth, nose, or oropharynx; and altered mental status. In addition to CYANOKIT^®, treatment of cyanide poisoning must include immediate attention to airway patency, adequacy of oxygenation and hydration, cardiovascular support, and management of any seizure activity.

Use caution in the management of patients with known anaphylactic reactions to hydroxocobalamin or cyanocobalamin. Allergic reactions may include anaphylaxis, chest tightness, edema, urticaria, pruritus, dyspnea, rash, and angioneurotic edema. Substantial increases in blood pressure may occur following treatment with CYANOKIT^®.

The most common adverse reactions (>5%) are transient and include chromaturia, erythema, rash (acneiform), increased blood pressure, nausea, headache, decreased lymphocyte percentage, and injection site reactions. Usage may interfere with some clinical laboratory evaluations. Due to potential photosensitivity patients should avoid direct sun until erythema resolves.

CYANOKIT^® is Pregnancy Category C and should be used during pregnancy only if the potential benefit justifies the potential risk. Safety and effectiveness of CYANOKIT^® have not been established in pediatrics.

Please see full Prescribing Information.

DISCLAIMER
The content of this Web site is not and should not be construed as medical advice. The content contained herein only constitutes commentary and is for educational and information purposes only. Reading this Web site, or any other interaction on this site, does not create a relationship between you and the Web site or its registered owner. As with any medical issue that may confront you in a particular situation, you should always consult a qualified healthcare professional.

This Web site is intended for United States of America (U.S.A.) residents only and is subject to all applicable U.S.A. laws. CYANOKIT^® is a registered trademark of Merck Santé s.a.s., licensed by Meridian Medical Technologies^®, Inc., a wholly owned subsidiary of King Pharmaceuticals^®, Inc. Copyright © 2010 Meridian Medical Technologies^®, Inc., a wholly owned subsidiary of King Pharmaceuticals^®, Inc. All rights reserved. MMT6577A 03/2010

The expert advice of a regional poison control center may be obtained by calling 1-800-222-1222.