Administering CYANOKIT®29
- The starting dose of CYANOKIT® for adults is 5 g (ie, both 2.5 g vials), administered by IV infusion over a total of 15 minutes, 7.5 minutes per vial
- Depending upon the severity of the poisoning and the clinical response, a second dose of 5 g may be administered by IV infusion up to a total dose of 10 g
- The rate of infusion for a potential second dose may range from 15 minutes (for patients in extremis) to 2 hours, as clinically indicated
Storage29
Lyophilized form: Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F). CYANOKIT® may be exposed, during short periods, to temperature variations of usual transport,b transport in the desert,c and freezing/defrosting cycles.d
Reconstituted solution (diluent not included): Up to 6 hours at a temperature not exceeding 40ºC (104°F). Do not freeze. Discard any unused portion after 6 hours.
a 0.9% sodium chloride injection is the recommended diluent (diluent not included). Lactated Ringer’s solution and 5% dextrose injection have also been found to be compatible with hydroxcobalamin.
b Usual transport defined as 15 days subjected to temperatures ranging from 5° to 40°C (41° to 104°F).
c Transport in the desert defined as 4 days subjected to temperatures ranging from 5° to 60°C (41° to 140°F).
d Freezing/defrosting cycles defined as 15 days subjected to temperatures ranging from –20° to 40°C (–4° to 104°F).
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