Conveniently packaged and easy to administer by paramedics or hospital-based medical personnel

Effectively used in Europe for more than 10 years2

 

30-month shelf life ensures kits can be kept in reserve and
are available when needed2

Important Safety Information
Most common adverse reactions (>5%) are transient and include chromaturia (red-colored urine), erythema (skin redness), rash, increased blood pressure, nausea, headache, decreased lymphocyte percent, and injection site reactions. Allergic reactions have been observed. Usage may interfere with some clinical laboratory evaluations.1

*A controlled animal study demonstrated the effect of hydroxocobalamin in CN-poisoned adult dogs that experienced cardiovascular recovery (characterized by increases in blood pressure) 1 to 3 minutes after initiation of infusion. The 75 and 150 mg/kg doses used are approximately equivalent to 5 and 10 g of hydroxocobalamin in humans.

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  • The starting dose of CYANOKIT® 5g (hydroxocobalamin for injection) antidote for adults is 5 g (ie, both 2.5 g vials), adminstered by IV infusion over 15 minutes

  • Depending on the severity of the poisoning and the clincal response, a second dose of 5 g may be administered by IV infusion up to a total dose of 10 g

  • The rate of infusion for a potential second dose may range from 15 minutes (for patients in extremis) to 2 hours, as clinically indicated

Storage
  • Lyophilized form: store at 25°C (77° F); excursions permitted to 15-30°C (59-86°F). CYANOKIT® antidote may be exposed, during short periods, to temperature variations of usual transport,† transport in the desert,‡ and freezing/defrosting cycles§

  • Reconstituted solution: Up to 6 hours at a temperature not exceeding 40°C (104°F). Do not freeze. Discard any unused portions after 6 hours.

30-month shelf life ensures kits can be kept in reserve and
are available when needed2

*Lactated Ringers Solution and 5% dextrose (D5W) have also been found to be compatible with hydroxocobalamin.
†Usual transport defined as 15 days submitted to temperature ranging from 5 to 40°C (41 to 104°F).
‡Transport in the desert defined as 4 days submitted to temperatures ranging from 5 to 60°C (41 to 140°F).
§Freezing/defrosting cycles defined as 15 days submitted to temperatures ranging from –20 to 40°C (–4 to 104°F).

 

 
For more information on CYANOKIT® antidote, please call (800) 755-5560, x3368 or contact Bound Tree Medical at (800) 533-0523 or www.boundtree.com.

Download full Prescribing Information.

References: 1. CYANOKIT®, antidote full Prescribing Information. Napa, Calif: Dey, L.P.; 2006. 2. Data on file. Durham, NC; EMD Pharmaceuticals; 2006. 3. Borron SW, Stonerook M, Reid F. Efficacy of hydroxocobalamin for the treatment of acute cyanide poisoning in adult beagle dogs. Clin Toxicol. 2006;44:5-15.

© 2007 Dey®
CYANOKIT® is a registered trademark of Merck Sante s.a.s. All rights reserved.