CYANOKIT® (hydroxocobalamin for injection)
5 g for intravenous infusion is indicated for the treatment of known or suspected
cyanide poisoning. If clinical suspicion of cyanide poisoning is high, CYANOKIT® should be administered without delay.
Cyanide poisoning may result from inhalation, ingestion, or dermal exposure. Prior
to administration of CYANOKIT®, smoke-inhalation
victims should be assessed for: exposure to fire or smoke in an enclosed area; presence
of soot around the mouth, nose, or oropharynx, and altered mental status. In addition
to CYANOKIT®, treatment of cyanide poisoning
must include immediate attention to airway patency, adequacy of oxygenation and
hydration, cardiovascular support, and management of any seizure activity.
Use caution in the management of patients with known anaphylactic reactions to hydroxocobalamin
or cyanocobalamin. Allergic reactions may include: anaphylaxis, chest tightness,
edema, urticaria, pruritus, dyspnea, rash, and angioneurotic edema. Substantial
increases in blood pressure may occur following CYANOKIT®
therapy. Usage may interfere with some clinical laboratory evaluations. Also, because
of its deep red color, hydroxocobalamin may cause hemodialysis machines to shut
down due to an erroneous detection of a "blood leak." This should be considered
before hemodialysis is initiated in patients treated with hydroxocobalamin. Due
to potential photosensitivity, patients should avoid direct sun until erythema resolves.
CYANOKIT® is Pregnancy Category C and should
be used during pregnancy only if the potential benefit justifies the potential risk.
Safety and effectiveness of CYANOKIT® have
not been established in pediatric patients. The most common adverse reactions (>5%)
are transient and include chromaturia, erythema, rash (predominantly acneiform),
increased blood pressure, nausea, headache, decreased lymphocyte percentage, and
injection site reactions.
Please see single 5-g vial full Prescribing Information. Please see two 2.5-g vial full Prescribing Information.
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