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Conveniently
packaged and easy to administer by
paramedics or hospital-based medical
personnel
Effectively used
in Europe for more than 10 years2
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30-month
shelf life ensures kits can be kept
in reserve and
are available when needed2
Important
Safety Information
Most common adverse reactions
(>5%) are
transient and include chromaturia (red-colored urine),
erythema (skin redness), rash, increased blood pressure,
nausea, headache, decreased lymphocyte percent, and
injection site reactions. Allergic reactions have been
observed. Usage may interfere with some clinical laboratory
evaluations.1
*A controlled animal
study demonstrated the effect of hydroxocobalamin
in CN-poisoned adult dogs that experienced
cardiovascular recovery
(characterized by increases in blood
pressure) 1 to 3 minutes after initiation
of infusion. The 75 and 150 mg/kg doses
used are approximately
equivalent to 5 and 10 g of hydroxocobalamin
in humans.
Download full Prescribing
Information
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- The
starting dose of CYANOKIT®
5g (hydroxocobalamin for injection)
antidote for adults is 5 g (ie,
both 2.5 g vials), adminstered
by IV infusion over 15 minutes
- Depending on the severity of
the poisoning and the clincal response,
a second dose of 5 g may be administered
by IV infusion up to a total dose
of 10 g
- The rate of
infusion for a potential second
dose may range from 15 minutes
(for patients in extremis)
to 2 hours, as clinically indicated
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Storage |
- Lyophilized
form: store at 25°C
(77° F); excursions permitted
to 15-30°C (59-86°F). CYANOKIT® antidote
may be exposed, during short periods,
to temperature
variations of usual transport,† transport
in the desert,‡ and freezing/defrosting
cycles§
- Reconstituted
solution: Up to 6 hours
at a temperature not exceeding 40°C
(104°F). Do not freeze. Discard
any unused portions after 6 hours.
30-month
shelf life ensures kits can be kept
in reserve and
are available when needed2
*Lactated Ringers Solution and 5%
dextrose (D5W) have also been found
to be compatible with hydroxocobalamin.
†Usual transport defined as
15 days submitted to temperature ranging
from 5 to 40°C (41 to 104°F).
‡Transport in the desert defined
as 4 days submitted to temperatures
ranging from 5 to 60°C (41 to 140°F).
§Freezing/defrosting cycles defined
as 15 days submitted to temperatures
ranging from –20 to 40°C
(–4 to 104°F).
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References: 1. CYANOKIT®,
antidote full Prescribing Information.
Napa, Calif: Dey, L.P.; 2006. 2.
Data on file. Durham, NC; EMD Pharmaceuticals;
2006. 3. Borron SW, Stonerook M,
Reid F. Efficacy of hydroxocobalamin
for the treatment of acute cyanide
poisoning in adult beagle dogs.
Clin Toxicol. 2006;44:5-15.
© 2007 Dey®
CYANOKIT® is a registered
trademark of Merck Sante s.a.s.
All rights reserved. |
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